South Africa has launched a major effort to strengthen occupational health for healthcare workers and safeguard the health of patients and others visiting health facilities. Strengthening administrative infection prevention and control (IPC) procedures will help reduce TB and other infections in healthcare facilities. The IPConnect suite of mobile health (mHealth) applications will help strengthen administrative IPC procedures and allow National Department of Health staff gather and analyze data for improved occupational health through targeted IPC resources and response. Healthcare staff are given access to IPConnect applications based on staff needs and duties and vary by application.